Pharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review
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منابع مشابه
Pharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review
Introduction ▼ Melatonin is a hormone produced by the pineal gland, regulating the circadian rhythm in mammals [1]. Exogenous administration of melatonin improves sleep quality [2], reduces jet lag [3], and possesses analgesic [4, 5], anti-oxidative [6, 7] and anti-inflammatory effects [6]. Melatonin is traditionally administered orally, but the drug displays a poor and variable bioavailability...
متن کاملPharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review.
BACKGROUND Melatonin is traditionally administered orally but has a poor and variable bioavailability. This study aims to present an overview of studies investigating the pharmacokinetics of alternative administration routes of melatonin. METHODS A systematic literature search was performed and included experimental or clinical studies, investigating pharmacokinetics of alternative administra...
متن کاملPharmacokinetics of Alternative Administration Routes of Melatonin: A Systematic Review
Introduction ▼ Melatonin is a hormone produced by the pineal gland, regulating the circadian rhythm in mammals [1]. Exogenous administration of melatonin improves sleep quality [2], reduces jet lag [3], and possesses analgesic [4, 5], anti-oxidative [6, 7] and anti-inflammatory effects [6]. Melatonin is traditionally administered orally, but the drug displays a poor and variable bioavailability...
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Treprostinil is available in three different formulations and four different routes of administration: Remodulin® (treprostinil sodium, intravenous and subcutaneous administration), Tyvaso® (treprostinil sodium, inhaled administration), and Orenitram® (treprostinil diolamine, oral administration) for the treatment of pulmonary arterial hypertension (PAH). Pharmacokinetic studies have been perfo...
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ژورنال
عنوان ژورنال: Drug Research
سال: 2015
ISSN: 2194-9379,2194-9387
DOI: 10.1055/s-0035-1565083